Which antibiotic class is associated with tendon rupture risk?

Which antibiotic class is associated with tendon rupture risk?

• A. Fluoroquinolones
• B. Macrolides
• C. Aminoglycosides
• D. Penicillins

Answer: (A)

Fluoroquinolones carry a recognized risk of tendinopathy and tendon rupture, especially in older adults and when combined with corticosteroid use. The exact mechanism isn’t fully understood, but these drugs may affect collagen synthesis and tenocyte health, weakening tendons and increasing rupture risk, with the Achilles tendon most commonly involved. This is a well-documented safety concern and is why this class is singled out for tendon-related issues. The other antibiotic classes listed do not have tendon rupture risk as a class effect. If tendon pain, swelling, or rupture symptoms appear during therapy, discontinue the drug and switch to an alternative antibiotic.

Fluoroquinolones carry a recognized risk of tendinopathy and tendon rupture, especially in older adults and when combined with corticosteroid use. The exact mechanism isn’t fully understood, but these drugs may affect collagen synthesis and tenocyte health, weakening tendons and increasing rupture risk, with the Achilles tendon most commonly involved. This is a well-documented safety concern and is why this class is singled out for tendon-related issues. The other antibiotic classes listed do not have tendon rupture risk as a class effect. If tendon pain, swelling, or rupture symptoms appear during therapy, discontinue the drug and switch to an alternative antibiotic.